Manipulation on the cellular scale is essential for many fundamental studies in biology. Manipulation methodologies could help researchers to understand the behavior of an entire organism, and at the same time be helpful in molecular dynamics/mechanics studies, e.g. by allowing monitoring and control of interaction between biomolecules. The acoustic based trapping/manipulations techniques do not provide quantitative information about the morphological changes in the trapped or manipulated microparticles or the biological objects. Therefore, the main aim of the project is to integrate optical based quantitative phase imaging (QPI) with the acoustic trapping for the biological specimens.